The Cambridge to Dole-Jura route also represents the airline’s first flights between the UK and France.
The new scheduled flights will operate on Mondays and Fridays.
The regional airport of the Franche-Comté province also offers access to neighbouring Burgundy.
Danube Wings will introduce a four-bottle wine allowance for passengers flying on the route.
David Surley, head of business development at Cambridge Airport, said: “This is a groundbreaking development with one of Europe’s rapidly developing airline companies and to such a beautiful and largely undiscovered region of France. This is the first of a number of exciting international services we plan to bring to Cambridge.”
Jan Rostas, CEO of Danube Wings, added: “Cambridge Airport is an important gateway to London, Cambridge and the East of England, and we are looking forward to promoting tourism across these areas of the UK and France with this convenient new service.”
The airport provides a shuttle service to Cambridge train station, and passengers can travel between the airport and the centre of London in around 90 minutes. The Dole-Jura service is the airport’s third destination, after Jersey and Verona, Italy.