The services will be operated by Stobart Air under a new deal announced last week.
This will see Flybe offering six new routes to Rennes and Caen Normandie in France; Groningen in the Netherlands; Münster Osnabrück and Cologne Bonn in Germany; and Antwerp, Belgium.
This will see a total of 102 weekly flights operating from the Essex gateway, which Flybe forecasts will be used by 200,000 passengers in the first year, rising to 700,000 by 2017.
Services to Rennes, Groningen and Münster Osnabrück will commence on June 5, with services to Cologne Bonn, Caen Normandie and Antwerp starting on July 3.
Flybe says it plans to steadily increase frequency on the new routes, including taking Antwerp and Rennes to double daily later this year.
Simon Fagan, chief operating officer, Stobart Air, said: “Each of these new routes will resonate with both business and leisure passengers. Prices are competitive, schedules are convenient, and the airports are efficient. From London Southend’s perspective, we will expect to deliver an extra 200,000 passengers in year one, rising to 700,000 passengers within three years.”